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Effects of 12 Weeks of Combined Exercise on Vascular Function-Related Inflammation Factors, Carotid Intima-Media Thickness and Physical Fitness in Obese 40s-Aged Women with Metabolic Syndrome
Korean J Sports Med 2019;37:184-194
Published online December 1, 2019;  https://doi.org/10.5763/kjsm.2019.37.4.184
© 2019 The Korean Society of Sports Medicine.

Kijin Kim

Department of Physical Education, College of Physical Education, Keimyung University, Daegu, Korea
Correspondence to: Kijin Kim
Department of Physical Education, College of Physical Education, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea
Tel: +82-53-580-5256, Fax: +82-53-580-5314, E-mail: Kjk744@kmu.ac.kr
Received November 5, 2019; Revised November 28, 2019; Accepted November 29, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Purpose: The purpose of this study was to investigate the effects of 12 weeks of combined exercise on vascular function-related inflammation, carotid intima-media thickness and fitness factors in obese middle-aged women with metabolic syndrome.
Methods: The subjects of this study were 40 middle-aged women in their 40s with metabolic syndrome but no specific disease. The exercise group performed aerobic exercise and resistance exercise five times a week for 12 weeks, and then measured body composition, blood pressure, vascular function-related inflammation factors, metabolic syndrome factors, carotid intima-media thickness, and physical factors.
Results: The exercise group showed a significant (p<0.05) reduction after exercise in all items related to body composition, systolic and diastolic blood pressure, and intima-media thickness of the right carotid and left carotid arteries. Exercise group showed a significant decrease (p<0.05) after exercise in interleukin-6, tumor necrosis factor-慣, leptin, and all items of glucose metabolism-related variables. The exercise group showed a significant (p<0.05) increase after exercise physical efficiency index, grip strength, sit-ups, and sit & reach. After 12 weeks of exercise training, the reduction of intima-media thickness of the carotid artery was significantly (p<0.05) correlated with the improvement of body weight, systolic and diastolic blood pressure, grip and sit & reach, blood HbA1c, and triglyceride concentration.
Conclusion: In conclusion, metabolic syndrome improved the body composition, blood glucose metabolism and lipid variables after 12 weeks of combined exercise program for obese middle-aged women. Significant improvement in blood pressure and carotid endometrial thickness, which is a function-related indicator, was confirmed.
Keywords : Exercise, Intima-media thickness, Metabolic syndrome, Woman
꽌 濡

궗利앺썑援(metabolic syndrome) 怨쇱엵 쁺뼇怨듦툒怨 醫뚯뾽 깮솢뿉 쓽븳 怨쇰룄븳 泥댁諛 利앷媛 몴쟻씤 쐞뿕슂씤쑝濡쒖꽌 蹂듬吏諛, 씤뒓由 빆꽦, 씠긽吏吏덊삁利, 삁븬利앷 벑씠 꽌濡 援곗쭛쓣 씠猷⑥뼱 굹굹硫, 삁쟾 삎꽦꽦뼢 긽깭, 뿼利앹쑀諛쒖긽깭, 鍮꾩븣肄붿삱꽦 吏諛⑷컙吏덊솚 諛 깮떇湲곌 씠긽 벑쓣 룷븿븯뒗 룞諛섏쭏솚怨 愿젴꽦쓣 媛吏꾨떎1. 궗利앺썑援곗 遺遺 怨쇱껜以묒씠굹 鍮꾨쭔쓣 룞諛섑븯怨 엳쑝硫, 씤뒓由곗빆꽦怨 룞留κ꼍솕利앹씠 빑떖쟻씤 슂씤쑝濡쒖꽌 떦눊蹂묎낵 삁愿湲곕뒫 븯 愿젴맂 빀蹂묒쬆씠 諛쒖깮븯硫댁꽌 吏덊솚쓽 쐞뿕꽦씠 뜑슧 媛以묐릺뒗 寃껋쑝濡 븣젮졇 엳떎2. 뵲씪꽌 룞留κ꼍솕利앹쓣 鍮꾨’븳 삁愿湲곕뒫 븯쁽긽 씤뒓由곗빆꽦怨 뜑遺덉뼱 궗利앺썑援곗쓽 빀蹂묒쬆 諛⑹ 諛 泥섏튂瑜 쐞빐꽌 留ㅼ슦 以묒슂븳 슂씤쑝濡 媛뺤“릺뼱빞 븳떎.

怨좏삁븬, 씠긽吏吏덊삁利, 떦눊蹂 벑쓽 궗利앺썑援곗 떖삁愿怨 빀蹂묒쬆 씠솚怨 遺덇遺꾩쓽 愿젴꽦쓣 媛吏怨 엳뒗뜲 諛섑빐꽌 珥덇린 궗利앺썑援 솚옄뱾 빀蹂묒쬆씠 諛쒖깮븯湲 쟾源뚯 삁愿 궡 蹂솕뿉 븳 젙솗븳 젙蹂대 솗씤븯吏 紐삵븯怨 엳뒗 寃쏀뼢씠 넂떎. 듅엳 궗利앺썑援곗 遺遺 삁愿빀蹂묒쬆쑝濡 궗留앹뿉 씠瑜대뒗 솗瑜좎씠 넂湲 븣臾몄뿉 빀蹂묒쬆뿉 뵲瑜 쐞뿕꽦쓣 媛먯냼떆궎湲 쐞빐꽌뒗 깮솢뒿愿 媛쒖꽑 諛 빟臾쇱쿂諛⑷낵 븿猿 궡以묐쭑 몢猿 吏꾨떒 벑쓣 씠슜븳 삁愿 궡 蹂솕瑜 젣떆빐 以뚯쑝濡쒖꽌 솚옄 뒪뒪濡 뜑슧 슚怨쇱쟻씠怨 쟻洹뱀쟻씤 吏덊솚愿由щ 븷 닔 엳룄濡 쑀룄븷 닔 엳쓣 寃껋씠떎. 삁愿湲곕뒫 븯뿉 쓽븳 빀蹂묒쬆 씠뻾怨쇱젙쓽 吏꾨떒諛⑸쾿쑝濡쒕뒗 愿긽룞留μ씠긽 吏꾨떒쓣 쐞븳 떖쟾룄, 떖옣슚냼 遺꾩꽍 諛 삁愿 議곗쁺닠, 뇤삁愿씠긽쓣 쐞븳 而댄벂꽣 떒痢듭눋쁺쓽 쁺긽吏꾨떒, 떦눊蹂묒꽦 留앸쭑蹂묒쬆쓽 븞寃궗, 떦눊蹂묒꽦 떊寃쎈퀝利앹쓽 洹쇱쟾룄寃궗 벑쓣 씠슜븳떎. 洹몃윭굹 젅李⑥쓽 踰덇굅濡쒖怨 寃쎌젣쟻 遺떞쓣 怨좊젮븯뿬 二쎌긽룞留κ꼍솕利 吏꾪뻾젙룄瑜 뙆븙븯湲 쐞븳 湲곕낯쟻씤 吏꾨떒諛⑸쾿쑝濡쒖꽌 寃쎈룞留 궡以묐쭑 몢猿(carotid intima-media thickness)瑜 遺꾩꽍븯뒗 寃쎈룞留 珥덉쓬뙆吏꾨떒踰뺤 떖삁愿怨꾩쭏솚쓽 엫긽쟻 吏뺥썑瑜 룊媛븯뒗 以묒슂븳 珥덇린寃궗 룄援щ줈 궗슜릺怨 엳떎3. Akasaka 벑4 353紐낆쓽 뵾뿕옄瑜 긽쑝濡 寃쎈룞留 珥덉쓬뙆瑜 씠슜븯뿬 二쎌긽寃쏀솕利앹쓽 珥덇린떒怨 삉뒗 삁愿 吏덊솚쓽 吏꾨떒뿉 쑀슜꽦쓣 遺꾩꽍븳 寃곌낵 룞留κ꼍솕쓽 삎깭븰쟻 諛 湲곕뒫쟻 蹂솕뒗 寃쎈룞留 珥덉쓬뙆瑜 궗슜븯뿬 룊媛븷 닔 엳뒗 寃껋쑝濡 蹂닿퀬븯떎. 삉븳 Hodis 벑5 湲곗〈쓽 愿긽룞留μ쭏솚쓣 媛吏 솚옄쓽 寃쎈룞留 궡以묐쭑 몢猿 吏꾪뻾씠 愿긽룞留μ쭏솚쓽 諛쒖깮쓣 삁痢≫븯硫, 씠뱾 솚옄쓽 寃쎈룞留 궡以묐쭑 몢猿 蹂솕뒗 삁愿쓽 二쎌긽寃쏀솕꽦 蹂꽦쓣 굹궡뒗 寃껋쑝濡 蹂닿퀬븯떎.

궗利앺썑援곗쓽 媛옣 몴쟻씤 吏덊솚씤 떖삁愿怨 吏덊솚 몴쟻씤 궗留 썝씤쑝濡 媛꾩<릺怨 엳쑝硫6, 삁愿湲곕뒫 븯 愿젴맂 룞留κ꼍吏(arterial stiffness) 샊 寃쏀솕利(atherosclerosis) 떖삁愿怨 吏덊솚쓽 媛옣 빑떖쟻씤 슂씤쑝濡 媛꾩<릺怨 엳떎7뒗 愿젏뿉꽌 궗利앺썑援 吏꾪뻾뿉 쓽븳 삁愿湲곕뒫 븯 愿젴맂 吏몴쓽 吏꾨떒 諛 諛⑹뒗 嫄닿컯愿由щ 쐞빐꽌 留ㅼ슦 以묒슂븳 怨좊젮궗빆뿉 빐떦븳떎. 뵲씪꽌 삁愿湲곕뒫 븯쓽 諛⑹ 샊 媛쒖꽑쓣 쐞빐꽌 留ㅼ슦 슚怨쇱쟻씤 諛⑸쾿쑝濡 媛꾩<릺怨 엳뒗 슫룞봽濡쒓렇옩 닔뻾슚怨쇰 遺꾩꽍븯뒗 怨쇱젙뿉꽌 寃쎈룞留 궡以묐쭑 몢猿섎 鍮꾨’븳 삁愿湲곕뒫 씠긽쓽 湲곕낯쟻씤 吏몴 뜑遺덉뼱 궗利앺썑援곗쓽 쐞뿕吏몴 諛 泥대젰슂씤 벑쓽 蹂솕뼇긽怨 愿젴꽦쓣 븿猿 遺꾩꽍븯뒗 寃껋 삁愿湲곕뒫 씠긽뿉 쓽븳 궗利앺썑援 諛 빀蹂묒쬆 諛⑹ 泥섏튂瑜 쐞븳 以묒슂븳 젙蹂대 젣怨듯빐 以 닔 엳쓣 寃껋씠떎. 洹쒖튃쟻씤 슫룞 궗利앺썑援곗쓽 쐞뿕吏몴 媛쒖꽑 臾쇰줎 삁븬媛먯냼뿉 슚怨쇱쟻씤 諛⑸쾿씠吏留 삁愿 寃쎌쭅쓣 鍮꾨’븳 삁愿湲곕뒫 븯瑜 諛⑹ 샊 泥섏튂븯湲 쐞븳 슫룞봽濡쒓렇옩쓽 吏곸젒쟻씤 슚怨쇱뿉 愿빐꽌뒗 뿬쟾엳 怨꾩냽쟻씤 뿰援ш 슂援щ맂떎怨8 吏쟻릺怨 엳떎. 궗利앺썑援곌낵 寃쎈룞留 궡以묐쭑 몢猿섏쓽 긽愿꽦뿉 븳 뿰援щ뒗 솢諛쒗엳 씠猷⑥뼱吏怨 엳쑝굹9,10 슫룞씠굹 떇씠議곗젅怨 媛숈 깮솢뒿愿 援먯젙쓣 넻븳 궗利앺썑援곗쓽 媛쒖꽑怨 寃쎈룞留 궡以묐쭑 몢猿섏쓽 긽愿꽦뿉 븳 뿰援ш껐怨쇰뒗 嫄곗쓽 뾾떎. 삉븳 빀蹂묒쬆諛쒖깮 吏묐떒11씠 븘땶 궗利앺썑援곗쓣 媛吏怨 엳쑝굹 빀蹂묒쬆씠 諛쒖깮븯吏 븡 룓寃 쟾 以묐뀈 鍮꾨쭔 뿬꽦뱾쓣 긽쑝濡 떎떆맂 뿰援щ뒗 뿬쟾엳 誘명씉븳 닔以씠떎.

씠뿉 蹂 뿰援ъ옄뒗 궗利앺썑援곗쓣 룞諛섑븳 룓寃 쟾 鍮꾨쭔 以묐뀈뿬꽦뱾쓣 긽쑝濡 12二쇨컙쓽 슫룞듃젅씠떇씠 삁븬, 寃쎈룞留 궡以묐쭑 몢猿, 삁愿湲곕뒫愿젴 뿼利 쑀諛쒖슂씤, 궗利앺썑援 슂씤 諛 泥대젰슂씤 벑뿉 誘몄튂뒗 쁺뼢怨 洹 愿젴꽦쓣 遺꾩꽍븿쑝濡쒖뜥 삁愿湲곕뒫 愿젴 빀蹂묒쬆 삁諛⑹쓣 쐞븳 쟻젅븳 吏移⑥쓣 젣怨듯븯怨좎옄 븯떎.

뿰援 諛⑸쾿

1. 뿰援 긽

蹂 뿰援ъ쓽 긽옄뒗 40 以묐뀈뿬꽦쑝濡쒖꽌 듅씠 吏덊솚 뾾쑝굹 National Cholesterol Education Panel-Adult Treatment Panel III쓽 궗利앺썑援 吏꾨떒湲곗씤 뿀由щ몮젅 >85 cm (븳援씤 뿬꽦), 삁以 以묒꽦吏諛⑸냽룄(triglyceride [TG]) ≥150 mg/dL, 怨좊룄 吏떒諛 肄쒕젅뒪뀒濡ㅻ냽룄(high-density lipoprotein cholesterol [HDL-C] <50 mg/dL (뿬꽦), 븞젙 떆 삁븬 ≥130/85 mm Hg, 怨듬났삁떦 ≥110 mg/dL쓽 5媛吏 빆紐 以 3媛吏 씠긽 빐떦븯뿬 궗利앺썑援곗쑝濡 吏꾨떒릺뒗 40紐낆쓣 援ъ꽦븯떎. 씠뱾 긽옄뒗 臾댁옉쐞濡 슫룞洹몃9 20紐낃낵 넻젣洹몃9 20紐낆쑝濡 援щ텇븯쑝硫, 슫룞洹몃9 12二쇨컙 蹂듯빀슫룞봽濡쒓렇옩쓣 닔뻾븯룄濡 븯쑝硫, 넻젣洹몃9 듅蹂꾪븳 슫룞봽濡쒓렇옩쓣 궪媛븯룄濡 븯떎. 긽옄뱾씠 떇씠議곗젅 넻젣븯吏 紐삵븯怨 룊긽떆 떇궗瑜 옄쑀濡寃 닔뻾븯룄濡 븯떎. 긽옄뱾쓽 떊泥댁쟻 듅吏뺤 Table 1怨 媛숇떎.

Table 1 . Physical characteristics of subjects

GroupAge (yr)Height (cm)Body weight (kg)BMI (kg/m2)%Fat
Exercise46.10±2.93161.00±8.2571.78±14.9127.60±4.0031.13±6.34
Control45.60±1.46162.90±5.5469.38±12.1926.01±3.4731.30±6.08

Values are presented as mean±standard deviation.

BMI: body mass index.



2. 떎뿕 諛⑸쾿

1) 蹂듯빀슫룞봽濡쒓렇옩

蹂듯빀슫룞봽濡쒓렇옩 쑀궛냼슫룞怨 빆꽦슫룞쓣 蹂묓뻾븯뒗 諛⑹떇쑝濡 12二쇨컙 떎떆븯룄濡 븯떎. 슫룞 鍮덈룄뒗 二쇰떦 3씪, 슫룞 媛뺣룄뒗 쑀궛냼슫룞 理쒕떖諛뺤닔쓽 60%–70%, 빆꽦슫룞 1 RM쓽 60%–70%뿉 빐떦븯뒗 媛뺣룄濡 12–15 RM쓽 2꽭듃 湲곗쑝濡 꽕젙븯뿬 떎떆븯떎. 슫룞웾 媛쒖씤蹂 봽濡쒓렇옩쓣 젣떆븯쑝硫 4二 媛꾧꺽쑝濡 슫룞 媛뺣룄 꽕젙쓣 옱援ъ꽦븯뒗뜲, 슫룞 以 떖諛뺤닔 痢≪젙怨 1 RM 痢≪젙쓣 넻빐꽌 媛곴컖 理쒕떖諛뺤닔 湲곗 60%–70% 諛 1 RM 湲곗 60%–70%쓽 쟻젙 媛뺣룄媛 쑀吏릺룄濡 븯떎. 슫룞봽濡쒓렇옩 듃젅뱶諛(treadmill)쓣 씠슜븳 嫄룰린 諛 議곌퉭쓽 쑀궛냼슫룞怨 빆꽦슫룞(踰ㅼ튂봽젅뒪, 뙏援쏀렣湲, 쐵紐몄씪쑝궎湲, 븯諛곕怨쇱떊쟾, 뒳愿젅 떊쟾, 뒳愿젅 援닿끝: 꽕移섎맂 湲곌뎄瑜 씠슜븯뿬 6醫낅ぉ 떎떆)쓽 蹂듯빀슫룞봽濡쒓렇옩쓣 쟻슜븯쑝硫, 以鍮꾩슫룞怨 젙由ъ슫룞쓣 룷븿븯뿬 쟾泥댁슫룞떆媛꾩쓣 60遺꾩쑝濡 援ъ꽦븯떎.

2) 痢≪젙룄援 諛 諛⑸쾿

紐⑤뱺 뵾뿕옄뱾 蹂 떎뿕 쟾怨 떎뿕 醫낅즺 48떆媛 썑 삤쟾 8–10떆 궗씠뿉 떊泥닿뎄꽦 諛 梨꾪삁, 寃쎈룞留 몢猿 벑쓣 痢≪젙븳 떎쓬 泥대젰쓣 痢≪젙븯떎.

(1) 떊泥닿뎄꽦: 떊泥닿뎄꽦쓽 듅꽦 InBody 3.0 (Biospace, Seoul, Korea)쓣 씠슜븯뿬 泥댁쨷쓣 痢≪젙븯쑝硫, 떊泥댁쭏웾吏닔(body mass index [BMI])뒗 泥댁쨷(kg)/떊옣2 (m)쓽 怨듭떇쑝濡 궛異쒗븯떎. 뿀由щ몮젅뒗 뒔怨 12踰 븯떒遺 옣怨⑤뒫 긽遺쓽 以묎컙遺쐞뿉꽌 痢≪젙븯쑝硫, 씠뿉 쓽븳 뿀由/뿁뜦씠 몮젅鍮(waist to hip ratio [WHR])瑜 궛異쒗븯떎.

(2) 븞젙 떆 삁븬 諛 寃쎈룞留 궡以묐쭑 몢猿: 삁븬 닔삁븬怨(HICO, Tokyo, Japan)瑜 씠슜븯뿬 痢≪젙븯쑝硫 긽옄瑜 쓽옄뿉 븠寃 븯怨 理쒖냼븳 5遺꾧컙쓽 븞젙 썑 긽諛뺤쓣 떖옣怨 媛숈 넂씠濡 븯뿬 2遺 媛꾧꺽쑝濡 2쉶 痢≪젙븯뿬 痢≪젙移섏쓽 룊洹좎쓣 궡怨 2쉶쓽 룊洹좎튂媛 5 mm Hg 씠긽 李⑥씠媛 굹硫 異붽濡 痢≪젙븯뿬 3쉶移섏쓽 룊洹좎쓣 궛異쒗뻽떎. 삁븬 痢≪젙 썑 寃쎈룞留 궡以묐쭑 몢猿(intima-media thickness)瑜 痢≪젙븯떎. 珥덉쓬뙆 쁺긽吏꾨떒옣移(G60s, Siemens, Germany)瑜 씠슜븯뿬 醫, 슦 寃쎈룞留μ쓣 媛곴컖 3遺쐞 痢≪젙븯뿬 媛옣 몢爰쇱슫 遺쐞쓽 媛믪쓣 몴移섎줈 븯떎.

(3) 븞젙 떆 삁븸 梨꾩랬: 븞젙 떆 삁븸 삁븬痢≪젙떆湲곗 룞씪븳 떆湲곗뿉 梨꾩랬븯떎. 梨꾩랬 쟾 12떆媛꾩쓽 湲덉떇 썑 긽셿젙留μ쓣 넻븯뿬 10 mL瑜 梨꾩랬븯떎. 梨꾩랬븳 삁븸 쓳怨좊 諛⑹븯湲 쐞빐 뿤뙆由 泥섎━븳 썑 3,000 rpm쑝濡 10遺꾧컙 썝떖遺꾨━ 븯뿬 삁옣留뚯쓣 遺꾨━븳 떎쓬 遺꾩꽍 쟾 源뚯 –70꼦뿉꽌 깋룞 蹂닿븯떎.

(4) 泥대젰 痢≪젙: 泥대젰 븙젰, 諛곌렐젰, 쐵紐몄씪쑝궎湲, 븠븘 쐵紐 븵쑝濡 援쏀엳湲, 븯踰꾨뱶뒪뀦뀒뒪듃 벑쓣 痢≪젙븯떎. 븙젰 諛 諛곌렐젰 븙젰怨(TKK, Tokyo, Japan) 諛곌렐젰怨(TKK)瑜 媛곴컖 씠슜븯쑝硫, 븠븘 쐵紐 븵쑝濡 援쏀엳湲곕뒗 뼇 諛쒕컮떏씠 痢≪젙湲곌뎄쓽 닔吏곷㈃뿉 셿쟾엳 떯룄濡 臾대쫷쓣 諛붾Ⅴ寃 렣怨 븠 썑 긽泥대 셿쟾엳 援쏀 뙏쓣 理쒕븳 六쀪퀬 2珥덇컙 젙吏븳 긽깭뿉꽌 湲곕줉븯떎. 쐵紐몄씪쑝궎湲곕뒗 留ㅽ듃 쐞뿉 늻슫 옄꽭뿉꽌 臾대쫷媛곷룄뒗 빟 140o 젙룄濡 援щ젮꽌 諛쒕컮떏쓣 諛붾떏뿉 遺숈씤 썑 쐵紐몄쓣 씪쑝耳 뙏轅덉튂媛 臾대쫷뿉 떯寃 븯뒗 룞옉쓣 1쉶濡 븯뿬 30珥덇컙 諛섎났슏닔瑜 痢≪젙븯떎. 븯踰꾨뱶 뒪뀦뀒뒪듃뒗 넂씠 35 cm쓽 듅媛뺣뿉꽌 遺꾨떦 30쉶 냽룄濡 3遺꾧컙 삤瑜대궡由ш린瑜 떎떆븯쑝硫, 슫룞씠 걹궃 뮘 1遺꾩뿉꽌 1遺 30珥, 2遺꾩뿉꽌 2遺 30珥, 3遺꾩뿉꽌 3遺 30珥덉쓽 留λ컯닔瑜 湲곕줉븯뿬 떎쓬쓽 怨듭떇쓣 쟻슜븯뿬 떊泥댄슚쑉吏닔(physical efficiency index [PEI])瑜 궛異쒗븳떎.

PEI =    슫(180)       3쉶 留λ컯닔쓽珥앺빀× 2   × 100

(5) 삁븸遺꾩꽍: 삁以 蹂씤 遺꾩꽍쓣 쐞빐꽌 12떆媛 씠긽 怨듬났 긽깭瑜 쑀吏븳 썑 二쇱젙以묒젙留(antecubital vein)뿉꽌 10 mL쓽 젙留ν삁쓣 梨꾪삁븯떎. 썝떖 遺꾨━ 썑 珥 肄쒕젅뒪뀒濡, TG, HDL-C, 諛룄吏떒諛 肄쒕젅뒪뀒濡(low-density lipoprotein cholesterol) 벑쓣 媛곴컖쓽 遺꾩꽍 kit (Shinyang Co., Seoul, Korea)瑜 씠슜븯뿬 냽룄瑜 궛異쒗븯떎. 삁泥 씤뒓由곕냽룄뒗 씤뒓由 痢≪젙떆빟(Insulin IRMA, Biosource; Belgium)쓣 궗슜븯뿬 radioimmunoassay踰뺤쑝濡 痢≪젙븯떎. 삁泥 쑀由ъ諛⑹궛냽룄뒗 spectrophotometer (Spectronic 601; Milton-Roy Ltd., Houston, TX, USA)瑜 씠슜븯뿬 슚냼鍮꾩깋踰뺤쑝濡 痢≪젙븯떎. 떦솕삁깋냼냽룄(HbA1c)뒗 씠삩援먰솚 怨좎꽦뒫 븸泥댄겕濡쒕쭏넗洹몃옒뵾踰 썝由(high pressure liquid chromatography)瑜 씠슜븯뿬 痢≪젙븯떎. High sensitivity C-reactive protein뒗 Food and Drug Administration濡쒕꽣 듅씤맂 N High Sensitivity CRP (Dade Behring, Germany) kit Behring Nephelometer 100 analyzer (Messer Griesheim, Germany)瑜 씠슜븯뿬 硫댁뿭鍮꾪긽踰뺤쑝濡 痢≪젙븯떎. 삁以 뿼利앷젴吏몴뿉 빐떦븯뒗 삁옣 tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), 젟떞(leptin) 諛 븘뵒룷꽖떞(adiponectin) 냽룄뒗 媛곴컖쓽 痢≪젙슜 kit (Biosource)瑜 궗슜븯뿬 諛⑹궗꽑硫댁뿭痢≪젙踰뺤쑝濡 痢≪젙븯떎.

3. 옄猷 泥섎━ 諛⑸쾿

痢≪젙寃곌낵뿉 븳 넻怨꾩쿂由щ뒗 SPSS ver. 17.0 (SPSS Inc., Chicago, IL, USA)쓣 씠슜븯뿬 媛 빆紐⑹쓽 룊洹 諛 몴以 렪李⑤ 궛異쒗븯쑝硫, 洹몃9 諛 떆湲 媛 쑀쓽李 寃젙쓣 쐞븯뿬 2썝 蹂웾諛섎났 遺꾩꽍踰뺤쓣 쟻슜븯떎. 洹몃9 諛 떆湲곗쓽 쑀쓽븳 긽샇옉슜씠 굹궇 寃쎌슦 洹몃9蹂 떆湲곌컙 paired t-test 떆湲곕퀎 洹몃9媛 t-test뿉 쓽븳 궗썑寃젙쓣 떎떆븯怨, 빆紐⑷컙 긽愿愿怨꾨뒗 Pearson 긽愿怨꾩닔瑜 궛異쒗븯떎. 넻怨꾩쟻 쑀쓽닔以 α=0.05濡 븯떎.

寃 怨

1. 떊泥 援ъ꽦

12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 떊泥닿뎄꽦쓽 蹂솕뒗 Table 2뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 泥댁쨷, 泥댁諛⑸쪧, 뿀由щ몮젅 諛 WHR 벑쓽 紐⑤뱺 빆紐⑹뿉꽌 슫룞 썑뿉 쑀쓽븳(p<0.05) 媛먯냼瑜 굹깉쑝굹 넻젣洹몃9 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎.

Table 2 . Changes of body composition

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
Body weight (kg)71.78±14.9169.71±14.2669.38±12.1969.61±12.120.08731.433*49.792*
BMI (kg/m2)27.60±4.0026.78±3.9826.01±3.4726.09±3.400.93835.014*52.949*
WHR0.92±0.080.87±0.650.88±0.130.86±0.120.8448.387*1.541
%Fat31.13±6.3429.14±6.4031.30±6.0831.48±5.730.42018.762*26.942

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, BMI: body mass index, WHR: waist to hip ratio.

*p<0.05.



2. 삁븬

12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 삁븬쓽 蹂솕뒗 Table 3뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 닔異뺢린 諛 씠셿湲 삁븬 紐⑤몢 슫룞 썑뿉 쑀쓽븳(p<0.05) 媛먯냼瑜 굹깉쑝굹 넻젣洹몃9 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎.

Table 3 . Changes of blood pressure

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
SBP (mm Hg)125.00±23.68111.75*±19.55126.38±11.42126.61±10.760.3617.128*16.037*
DBP (mm Hg)82.50±18.0373.50*±13.0983.98±12.7784.25±8.810.2452.7917.752*

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, SBP: systolic blood pressure, DBP: diastolic blood pressure.

*p<0.05.



3. 삁以 궗씠넗移댁씤 냽룄

12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 삁以 궗씠넗移댁씤냽룄瑜 鍮꾨’븳 삁愿뿼利 吏몴뱾쓽 蹂솕뒗 Table 4뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 紐⑤뱺 빆紐⑹뿉꽌 媛먯냼븯뒗 寃쏀뼢쓣 굹깉뒗뜲, IL-6, TNF-α, 젟떞 벑쓽 빆紐⑹뿉꽌뒗 슫룞 썑 쑀쓽븳(p<0.05) 媛먯냼瑜 굹깉쑝硫, 븘뵒룷꽖떞 슫룞 썑 쑀쓽븯寃(p<0.05) 利앷븯떎. 洹몃윭굹 넻젣洹몃9 紐⑤뱺 빆紐⑹뿉꽌 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎.

Table 4 . Changes of blood concentration of cytokines

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
Fibrinogen (mg/dL)319.25±77.37303.95±47.03319.30±34.88322.55±36.150.4050.6781.607
CRP (mg/L)0.09±0.160.13±0.150.18±0.210.11±0.870.5840.4124.573*
IL-6 (pg/dL)15.78±2.5913.73*±2.6513.47±1.4113.24±1.325.263*19.630*12.399*
Adiponectin (mg/dL)84.49±21.8790.59*±19.5279.47±16.3877.99±16.882.2427.550*20.235*
PAI-1 (mg/dL)36.04±8.5239.321±18.7441.73±8.4845.05±12.613.2001.7560.001
TNF-α (pg/dL)59.89±24.5336.66*,±8.3671.11±22.4965.21±22.1512.614*20.451*7.237*
Leptin (ug/L)20.55±10.9713.10*±7.0315.08±8.6314.67±7.550.54328.824*23.065*

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, CRP: C-reactive protein, IL-6: interleukin-6, PAI-1: plasminogen activator inhibitor-1, TNF-α: tumor necrosis factor-α.

*p<0.05 2-way ANOVA or compared to pre-value in t-test of post hoc; Compared to control value in t-test of post hoc.



4. 삁以 湲猷⑥퐫뒪 諛 吏吏덈궗愿젴 蹂씤

12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 삁以 湲猷⑥퐫뒪 궗愿젴 蹂씤쓽 蹂솕뒗 Table 5뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 湲猷⑥퐫뒪, HbA1c, 씤뒓由 냽룄 諛 homeostatic model assessment 벑쓽 紐⑤뱺 빆紐⑹뿉꽌 슫룞 썑뿉 쑀쓽븳(p<0.05) 媛먯냼瑜 굹깉쑝굹 넻젣洹몃9 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎. 12二쇨컙쓽 蹂듯빀슫룞 썑 삁以 吏吏덈궗愿젴 蹂씤쓽 蹂솕뒗 Table 6뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 珥앹퐳젅뒪뀒濡, HDL-C 諛 以묒꽦吏諛 냽룄 벑쓽 빆紐⑹뿉꽌 슫룞 썑뿉 쑀쓽븳(p<0.05) 媛먯냼瑜 굹깉쑝굹 넻젣洹몃9 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎.

Table 5 . Changes of blood concentrations of glucose metabolism-related parameters

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
Glucose (mg/L)115.30±44.29103.35*±42.99117.60±10.10117.65±9.351.81016.775*17.058*
HbA1c (%)8.14±1.016.32*±1.427.09±0.646.82±0.900.88553.552*29.405*
Insulin (uIU/mL)14.38±5.7310.84*,±3.3315.84±3.5115.92±3.281.13311.998*13.060*
HOMA3.93±1.682.71*±1.223.99±0.853.91±0.910.78321.092*22.521*

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, HOMA: homeostatic model assessment.

*p<0.05 2-way ANOVA or compared to pre-value in t-test of post hoc; Compared to control value in t-test of post hoc.


Table 6 . Changes of blood concentration of lipid profiles

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
TC (mg/dL)196.50±26.53189.85*±26.84192.25±16.95197.45±10.321.7140.0966.418*
FFA (mg/dL)592.05±245.82576.85±190.39578.90±163.15536.90±136.120.2351.4940.328
HDL-C (mg/dL)49.83±8.9654.02*±10.6149.88±13.3147.90±12.741.9471.1829.213*
LDL-C (mg/dL)130.60±22.69138.30±22.13130.80±10.80133.80±16.252.3673.8880.389
TG (mg/dL)154.50±82.30114.90*±58.67151.10±17.44149.50±12.281.8747.211*10.174*

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, TC: total cholesterol, FFA: free fatty acid, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density lipoprotein-cholesterol, TG: triglyceride.

*p<0.05.



5. 寃쎈룞留 궡以묐쭑 몢猿

12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 寃쎈룞留 궡以묐쭑 몢猿섏쓽 蹂솕뒗 Table 7뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 슦寃쎈룞留 諛 醫뚭꼍룞留 紐⑤뱺 빆紐⑹뿉꽌 슫룞 썑뿉 쑀쓽븳(p<0.05) 媛먯냼瑜 굹깉쑝굹 넻젣洹몃9 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎.

Table 7 . Changes of intima-media thickness of carotid artery

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
Rt carotid artery (mm)0.70±0.180.56*±0.130.64±0.080.58±0.130.34111.912*1.906
Lt carotid artery (mm)0.68±0.170.57*±0.120.63±0.120.63±0.130.0054.096*4.096*

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, Rt: right, Lt: left.

*p<0.05.



6. 泥대젰

12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 泥대젰쓽 蹂솕뒗 Table 8뿉꽌 굹궃 諛붿 媛숈뜲, 슫룞洹몃9 PEI, 븙젰, 쐵紐몄씪쑝궎湲 諛 泥댁쟾援 벑쓽 빆紐⑹뿉꽌 슫룞 썑뿉 쑀쓽븳(p<0.05) 利앷瑜 굹깉쑝굹 넻젣洹몃9 슫룞 쟾썑 媛꾩뿉 쑀쓽븳 李⑥씠媛 뾾뿀떎.

Table 8 . Changes of physical fitness

ItemExerciseControlTwo-way repeated ANOVA (F-value)



PrePostPrePostGroupTimeGroup×Time
PEI (%)57.58±7.7362.12*±7.7664.10±16.2062.86±14.480.9264.595*14.181*
Back muscular strength (kg)56.37±23.4656.92±25.7057.57±32.7759.25±32.370.0400.2500.064
Grip strength (kg)29.29±9.5033.00*±9.3331.02±10.2031.44±9.390.00129.098*18.465*
Sit-up (frequency)12.75±7.2515.60*±6.9615.50±2.9615.45±2.780.60912.037*12.912*
Sit & reach (cm)10.83±10.9713.96*±7.9712.38±3.4112.20±3.570.0023.9675.027*

Values are presented as mean±standard deviation.

ANOVA: analysis of variance, PEI: physical efficiency index.

*p<0.05.



7. 슫룞듃젅씠떇 썑 빆紐⑸퀎 蹂솕 젙룄쓽 愿젴꽦

12二쇨컙 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 빆紐⑸퀎 蹂솕 젙룄쓽 愿젴꽦 Table 9뿉꽌 굹궃 諛붿 媛숈뜲, 닔異뺢린 삁븬쓽 蹂솕뿉 빐꽌뒗 泥댁쨷, BMI, HbA1c, TG, IL-6, 븘뵒룷꽖떞 諛 븙젰 벑쓽 蹂솕 젙룄 쑀쓽븳(p<0.05) 긽愿愿怨꾨 굹깉쑝硫, 씠셿湲 삁븬쓽 蹂솕 젙룄뒗 泥댁쨷, TG, IL-6, 븘뵒룷꽖떞 諛 븙젰 벑쓽 蹂솕 젙룄 쑀쓽븳(p<0.05) 긽愿愿怨꾨 굹깉떎. 삉븳 슦寃쎈룞留 궡以묐쭑 몢猿섏쓽 蹂솕 젙룄뒗 泥댁쨷, BMI, HbA1c, TG, 븙젰 諛 泥댁쟾援 벑쓽 蹂솕 젙룄 쑀쓽븳(p<0.05) 긽愿愿怨꾨 굹깉쑝硫, 醫뚭꼍룞留 몢猿섏쓽 蹂솕 젙룄뒗 泥댁쨷, HbA1c, TG, 븙젰 諛 泥댁쟾援 벑쓽 蹂솕 젙룄 쑀쓽븳(p<0.05) 긽愿愿怨꾨 굹깉떎. 泥대젰슂씤 以 떖룓湲곕뒫뿉 빐떦븯뒗 PEI 蹂솕뒗 닔異뺢린삁븬 蹂솕 諛 슦寃쎈룞留 궡以묐㎘ 몢猿 蹂솕 媛곴컖 –0.230 諛 –0.146쓽 긽愿怨꾩닔瑜 굹깉쑝굹 넻怨꾩쟻 쑀쓽꽦 뾾뿀떎. 삉븳 Fig. 1뿉꽌 굹궃 諛붿 媛숈씠 醫뚭꼍룞留 몢猿섏쓽 蹂솕 젙룄뒗 닔異뺢린 諛 씠셿湲 삁븬쓽 蹂솕 젙룄 쑀쓽븳(p<0.05) 긽愿愿怨꾨 굹깉떎.

Table 9 . Correlation coefficients among differences between pre- and post-exercise training in parameters

VariableSBPΔDBPΔRCCAΔLCCAΔ
Body weightΔ0.435**0.332*0.516**0.370*
BMIΔ0.424**0.2060.389*0.289
HbA1cΔ0.423**0.2280.404**0.483**
TGΔ0.474**0.517**0.514**0.448*
IL-6Δ0.391*0.422**0.1640.029
AdiponectinΔ−0.480**−0.412**0.099−0.181
Grip strengthΔ−0.465**−0.565**−0.581**−0.534**
Sit & reachΔ−0.281−0.210−0.530**−0.458**

Δ: difference between pre and post-value, SBP: systolic blood pressure, DBP: diastolic blood pressure, RCCA: intima-media thickness of right carotid artery, LCCA: intima-media thickness of left carotid artery, BMI: body mass index, TG: triglyceride, IL-6: interleukin-6.

*p<0.05, **p<0.01.


Fig. 1. Correlation between blood pressure differences and difference of intima-media thickness of left carotid artery after exercise training. SBP: systolic blood pressure, DBP: diastolic blood pressure.
怨 李

蹂 뿰援щ뒗 궗利앺썑援곗뿉 빐떦븯吏留 룞諛섏쭏솚씠 뾾뒗 醫뚯뾽 以묐뀈뿬꽦쓣 긽쑝濡 12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 떊泥닿뎄꽦, 泥대젰, 삁븬, 삁以 蹂씤, 寃쎈룞留 궡以묐쭑 몢猿 벑뿉 誘몄튂뒗 쁺뼢쓣 遺꾩꽍븿쑝濡쒖뜥 슫룞듃젅씠떇씠 以묐뀈 鍮꾨쭔 뿬꽦쓽 삁愿빀蹂묒쬆 諛쒖깮슂씤뿉 誘몄튂뒗 쁺뼢쓣 궡렣蹂닿퀬옄 븯떎. 遺꾩꽍寃곌낵 12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 궗利앺썑援곗쓣 媛吏 以묐뀈뿬꽦뱾쓽 떊泥닿뎄꽦怨 泥대젰닔以쓣 뼢긽떆耳곗쑝硫, 삉븳 븞젙 떆 삁븬怨 寃쎈룞留 궡以묐쭑 몢猿섎뒗 12二 슫룞 썑 쑀쓽븳(p<0.05) 媛먯냼슚怨쇰 굹깉떎.

슫룞듃젅씠떇 떊泥닿뎄꽦 諛 떖삁愿 吏덊솚 쐞뿕쓣 媛쒖꽑떆궗 닔 엳뒗 媛옣 寃쎌젣쟻씠硫, 떎뻾 媛뒫븳 鍮꾩빟由ы븰쟻 슂踰뺤씠떎. 듅엳 吏援ъ꽦슫룞 蹂듦컯 궡 궡옣吏諛⑹쓣 媛먯냼떆궗 닔 엳뒗 슚怨쇱쟻씤 諛⑸쾿쑝濡 꼸由 븣젮졇 엳떎12. 蹂 뿰援ш껐怨쇱뿉꽌룄 슫룞洹몃9씠 떊泥닿뎄꽦쓽 紐⑤뱺 빆紐⑹뿉꽌 쑀쓽븯寃(p<0.05) 媛먯냼븯뒗 슚怨쇰 굹궦 寃껋 蹂듯빀슫룞봽濡쒓렇옩씠 遺쟻 뿴웾냼紐⑤ 굹궡뒗뜲 쁽븳 룄쓣 以 寃껋쑝濡 媛꾩<맂떎. 듅엳 泥대젰愿젴 遺遺 빆紐⑹씠 媛쒖꽑맖쑝濡쒖뜥 蹂듯빀슫룞봽濡쒓렇옩쓽 湲띿젙쟻씤 슚怨쇰줈 媛꾩<맂떎. 슫룞봽濡쒓렇옩쓽 湲띿젙쟻씤 슚怨쇰뒗 以묐뀈 鍮꾨쭔뿬꽦쓽 嫄닿컯媛쒖꽑쓣 쐞빐꽌 泥대젰닔以쓽 뼢긽씠 떊泥닿뎄꽦뿉 鍮꾪빐꽌 긽쟻쑝濡 뜑슧 以묒슂븳 吏몴媛 맆 닔 엳떎뒗 愿젏뿉꽌 留ㅼ슦 以묒슂븳 쓽誘몃줈 諛쏆븘뱾뿬졇빞 븳떎. 듅엳 씠윭븳 泥대젰뼢긽 떊泥닿뎄꽦 蹂솕 뜑遺덉뼱 鍮꾨쭔씤쓽 궗利앺썑援 쑀蹂묐쪧 臾쇰줎 궗留앸쪧쓣 셿솕떆궎뒗뜲 留ㅼ슦 以묒슂븳 吏몴濡 븿猿 怨좊젮릺뼱빞 븯硫, 蹂 뿰援ъ쓽 以묒슂븳 吏몴씤 삁愿湲곕뒫쓽 媛쒖꽑쓣 넻빐꽌 떖삁愿 吏덊솚쓽 쑀蹂묐쪧쓣 굹궡뒗뜲 以묒슂븳 吏몴濡 怨좊젮릺뼱빞 븳떎뒗 愿젏뿉꽌 湲띿젙쟻씤 슚怨쇰줈 媛꾩<맆 닔 엳떎. 泥대젰 뼢긽쓽 꽭遺쟻씤 吏몴뱾쓣 궡렣蹂대㈃ 媛옣 以묒슂븳 泥대젰 슂씤뿉 빐떦븯뒗 떖룓湲곕뒫쓽 吏몴媛 릺뒗 븯踰꾨뱶 뒪뀦뀒뒪듃쓽 PEI媛 쁽븯寃 뼢긽릺뿀쑝硫, 븘슱윭 理쒓렐 泥대젰 뼢긽怨 愿젴븯뿬 떖룓湲곕뒫쓽 떒씪吏몴留 怨좊젮릺뒗 寃껋 諛붾엺吏곹븯吏 븡떎뒗 吏쟻쓣 怨좊젮븯뿬 븙젰쓣 以묒떖쑝濡 븳 洹쇰젰 뼢긽쓽 蹂묓뻾슚怨13룄 以묒슂븯寃 媛꾩<릺뼱빞 븯뒗뜲, 蹂 뿰援ъ뿉꽌 슫룞洹몃9씠 븙젰쓽 쑀쓽븳(p<0.05) 뼢긽쓣 굹깂쑝濡쒖뜥 鍮꾨쭔 以묐뀈뿬꽦뿉寃 쟻슜맂 蹂듯빀슫룞봽濡쒓렇옩쓽 湲띿젙쟻씤 슚怨쇰 솗씤븷 닔 엳뿀떎. 븙젰 끂솕怨쇱젙뿉꽌 以묒슂븳 嫄닿컯쐞뿕吏몴뿉 빐떦븯뒗 洹쇱쑁媛먯냼利앹쓽 以묒슂븳 吏몴濡 媛꾩<릺怨 엳뒗뜲13, 蹂 뿰援ъ뿉꽌 쁽븳 슫룞슚怨쇰 솗씤떆耳 以뚯쑝濡쒖뜥 嫄닿컯愿젴 以묒슂븳 吏몴뿉 빐떦븿쓣 븣 닔 엳뿀떎. 슫룞 듃젅씠떇쓣 넻븳 泥댁諛 媛먯냼뿉 븳 留롮 愿떖怨 뿰援ъ뿉룄 遺덇뎄븯怨 吏諛⑹넀떎쓣 利앷떆궗 닔 엳뒗 媛옣 슚怨쇱쟻씤 슫룞諛⑸쾿 뿬쟾엳 紐낇솗븯寃 젣떆릺吏 븡怨 엳떎14뒗 愿젏뿉꽌 떎뼇븳 媛뺣룄쓽 쟻슜쓣 넻븳 怨꾩냽쟻씤 遺꾩꽍씠 슂援щ맂떎. 蹂 뿰援ъ뿉꽌 슫룞洹몃9 泥댁쨷쓣 鍮꾨’븳 떊泥닿뎄꽦쓽 紐⑤뱺 吏몴뿉꽌 쁽븳 媛먯냼슚怨쇰 굹깂쑝濡쒖뜥 쟻슜맂 蹂듯빀슫룞봽濡쒓렇옩씠 以묐뀈뿬꽦쓽 떊泥닿뎄꽦 媛쒖꽑뿉 留ㅼ슦 슚怨쇱쟻씤 봽濡쒓렇옩씠 맆 닔 엳떎뒗 寃껋쓣 븣 닔 엳뿀떎.

12二쇨컙쓽 슫룞듃젅씠떇뿉 뵲瑜 삁以 湲猷⑥퐫뒪 궗愿젴 蹂씤쓣 遺꾩꽍빐蹂 寃곌낵 슫룞洹몃9쓽 寃쎌슦 怨듬났 떆 삁以 湲猷⑥퐫뒪瑜 鍮꾨’븳 紐⑤뱺 빆紐⑹뿉꽌 넻怨꾩쟻쑝濡 쑀쓽븯寃(p<0.05) 媛먯냼맖쑝濡쒖뜥 씤뒓由곗빆꽦씠 쁽븯寃 媛쒖꽑릺뒗 寃껋쑝濡 굹궗떎. 삉븳 삁以 吏吏 蹂씤뿉꽌룄 슫룞洹몃9 珥앹퐳젅뒪뀒濡ㅺ낵 以묒꽦吏諛 냽룄뿉꽌 쑀쓽븯寃(p<0.05) 媛먯냼븯쑝硫, HDL-C 냽룄媛 쑀쓽븯寃(p<0.05) 利앷븯뒗 슫룞슚怨쇰 굹깂쑝濡쒖뜥 삁以 吏吏 蹂씤쓽 蹂솕뒗 슫룞봽濡쒓렇옩쓽 湲띿젙쟻씤 슚怨쇰 넻빐꽌 궗꽦吏덊솚쓽 쐞뿕吏몴뱾씠 쟾泥댁쟻쑝濡 媛쒖꽑릺뒗 寃껋쑝濡 굹궗떎. 洹쒖튃쟻씤 슫룞씠 씤뒓由곗빆꽦怨 븿猿 삁以 吏吏 蹂씤쓽 媛쒖꽑쓣 쐞븳 슚怨쇱쟻씤 泥섏튂諛⑸쾿씠 맂떎뒗 寃껋 留롮 꽑뻾뿰援15瑜 넻빐꽌 꼸由 蹂닿퀬맂 諛 엳뒗뜲, 씠 怨쇱젙뿉꽌 泥댁쨷媛먯냼媛 룞諛섎릺吏 븡쓣 寃쎌슦 洹 媛쒖꽑슚怨쇨 씪떆쟻쑝濡 굹굹뒗 寃쏀뼢16씠 엳뒗 諛섎㈃뿉 泥댁쨷媛먯냼媛 룞諛섎맆 寃쎌슦 鍮꾧탳쟻 吏냽쟻씤 寃껋쑝濡 蹂닿퀬17맖쑝濡쒖뜥 蹂 뿰援ъ뿉꽌 媛숈씠 泥댁쨷쓣 鍮꾨’븳 떊泥닿뎄꽦쓽 湲띿젙쟻씤 슚怨쇨 룞諛섎맆 닔 엳룄濡 븯뒗 寃껋쓣 以묒슂븯寃 怨좊젮븷 븘슂꽦씠 엳쓣 寃껋쑝濡 깮媛곷맂떎.

씤뒓由곗빆꽦怨 삁以 吏吏 蹂씤쓽 媛쒖꽑 궗꽦吏덊솚 쑀諛쒖쓽 以묒슂븳 湲곗쟾쟻 슂씤뿉 빐떦븯뒗 泥대궡 뿼利앹몴 媛쒖꽑뿉룄 愿뿬븷 닔 엳쓣 寃껋쑝濡 湲곕릺뒗뜲, 泥대궡 뿼利앷낵 愿젴맂 궗씠넗移댁씤쓽 쑀諛쒖긽깭뒗 泥대궡 뿼利앸컻깮怨쇱젙뿉꽌 以묒슂븳 쁺뼢쓣 誘몄튂硫댁꽌 궗꽦吏덊솚 쑀蹂묐쪧 벑뿉 떖媛곹븳 쁺뼢쓣 誘몄튂湲 븣臾몄뿉 嫄닿컯긽깭 쑀吏뒗 臾쇰줎 끂솕怨쇱젙쓽 移섎ℓ 諛쒖깮 諛 씤吏湲곕뒫 븯뿉룄 떖媛곹븳 쁺뼢쓣 誘몄튂뒗 寃껋쑝濡 蹂닿퀬맂 諛 엳떎18. 뵲씪꽌 泥대궡 궗씠넗移댁씤냽룄뒗 嫄닿컯 諛 吏덊솚긽깭쓽 吏꾨떒 諛 利앹긽쓣 솗씤븯湲 쐞븳 쑀슜븳 깮泥댁몴濡쒖꽌 泥섏튂怨쇱젙쓽 以묒슂븳 슚怨쇱 愿젴맂 吏몴媛 릺湲곕룄 븳떎.

Drexel 벑19 45紐낆쓽 嫄닿컯븳 醫뚯뾽 以묐뀈꽦씤쓣 긽쑝濡 8二쇨컙 吏援ъ꽦슫룞 떆 吏곸엫쓽 쑀삎(eccentric vs. concentric)씠 떖삁愿 吏덊솚 쐞뿕씤옄뿉 誘몄튂뒗 쁺뼢쓣 遺꾩꽍븳 寃곌낵 떊쟾꽦(eccentric) 슫룞 떊吏꾨궗 諛 빆뿼利 슚怨쇨 엳쑝硫 떦 궡꽦쓣 쑀쓽븯寃 媛쒖꽑떆耳곗쑝硫, 떒異뺤꽦(concentric) 슫룞 以묒꽦吏諛 닔以쓣 媛쒖꽑떆궓 寃껋쑝濡 蹂닿퀬븯떎. 씠瑜 넻빐 蹂 뿰援ъ뿉꽌 쟻슜맂 蹂듯빀슫룞 떊泥닿뎄꽦쓽 蹂솕 뜑遺덉뼱 삁以 吏吏덇낵 삁떦 議곗젅젰쓣 利앷떆궎뒗뜲 슚怨쇱쟻씤 寃껋쑝濡 깮媛곷맂떎.

洹쒖튃쟻씤 쑀궛냼슫룞 떖삁愿 吏덊솚쓽 쐞뿕쓣 媛먯냼떆궎怨 룞留κ린뒫쓣 蹂댁〈븯뒗뜲, 씠뒗 빆뿼利 슚怨쇱뿉 쓽븳 삁愿蹂댄샇슚怨 븣臾몄쑝濡 媛꾩<릺怨 엳떎20. 븘뀒濡ъ꽦 룞留κ꼍솕利앹쓽 蹂묒씤쑝濡쒕뒗 留뚯꽦쟻 닔以쓽 뿼利앷낵 궡뵾쓽 湲곕뒫옣븷瑜 룷븿븯怨 엳뒗뜲21, 솢꽦솕맂 떒빑援ъ 떇꽭룷뒗 뿼利앸컲쓳쓽 떆옉怨 吏꾪뻾쓽 以묒옱옄씤 뿼利앹쑀諛쒖꽦 궗씠넗移댁씤쓣 遺꾨퉬븯湲 븣臾몄뿉 二쎌긽寃쏀솕利 諛쒖깮뿉 以묒슂븳 뿭븷쓣 븯硫, 삁愿꽭룷뿉 吏곸젒 쁺뼢쓣 誘몄퀜 삁愿湲곕뒫쓽 옣븷瑜 씪쑝궎寃 맂떎22. 듅엳 IL-6뒗 궡뵾꽭룷 遺李⑸텇옄쓽 諛쒗쁽쓣 쑀룄븯怨 궡뵾 nitric oxide synthase (eNOS)쓽 솢꽦솕瑜 뼲젣븿쑝濡쒖뜥 궡뵾꽭룷뿉 吏곸젒쟻쑝濡 쁺뼢쓣 誘몄튇떎. 蹂 뿰援ш껐怨 12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 鍮꾨쭔 以묐뀈뿬꽦뱾쓽 삁以 IL-6, TNF-α 냽룄瑜 쑀쓽븯寃(p<0.05) 媛먯냼떆耳곕떎. Elosua 벑23 怨좊졊옄瑜 긽쑝濡 떊泥댄솢룞怨 뿼利앹꽦 깮泥 몴吏옄쓽 긽愿꽦쓣 遺꾩꽍븳 寃곌낵, 媛꾪뿉쟻씤 媛踰쇱슫 슫룞 媛뺣룄뿉꽌룄 뿼利앹꽦 깮泥댁씤옄뱾씠 쑀쓽븯寃 媛먯냼븳 寃껋쑝濡 蹂닿퀬븯떎. 삉븳 Lesniewski 벑24 쑀궛냼슫룞씠 끂솕 씛伊먯쓽 룞留μ뿼利앹뿉 誘몄튂뒗 쁺뼢쓣 遺꾩꽍븳 寃곌낵, 14二쇨컙쓽 옄諛쒖쟻씤 諛뷀 떖由ш린뒗 룞留 궡 IkB kinase-Nuclear factor kappa B 솢꽦솕, 궗씠넗移댁씤(IL-1, IL-6, Interferon-γ, TNF-α) 諛쒗쁽, 쇅긽 諛 떇꽭룷 移⑥쑄 諛 삁愿湲곕뒫쓣 媛쒖꽑떆궎뒗 寃껋쑝濡 굹궗쑝굹 젇 씛伊먯뿉꽌뒗 씠윭븳 쁽긽씠 굹굹吏 븡븯떎. 씠뱾 씠윭븳 寃곌낵瑜 넻빐 洹쒖튃쟻씤 떊泥댄솢룞 삁愿 궡 빆뿼利 슚怨쇰 諛쒖깮떆耳 끂솕뿉 뵲瑜 삁愿 옣븷瑜 媛쒖꽑떆궗 닔 엳뒗 寃껋쑝濡 寃곕줎 궡졇떎. 듅엳 IL-6뒗 깮泥닿린뒫쓽 빆긽꽦 쑀吏뿉 寃곗젙쟻씤 쁺뼢쓣 誘몄튂뒗 吏몴濡쒖꽌 뿼利앹쑀諛쒓낵 빆 뿼利앷린뒫쓣 븿猿 媛吏硫댁꽌 뿼利앸컻깮怨 愿젴맂 泥대궡 깮由ъ쟻 湲곕뒫 諛 硫댁뿭湲곕뒫議곗젅쓽 빑떖쟻 吏몴濡 媛꾩<릺怨 엳떎. 蹂 뿰援ъ뿉꽌 씠윭븳 삁以 IL-6 냽룄뒗 슫룞洹몃9뿉꽌 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 쁽븳 媛먯냼瑜 굹깉쑝硫, 씠윭븳 媛먯냼 젙룄뒗 닔異뺢린 諛 씠셿湲 삁븬쓽 媛먯냼 젙룄 쑀쓽븳(p<0.05) 긽愿怨꾩닔瑜 굹깂쑝濡쒖뜥 삁愿湲곕뒫 議곗젅뿉 以묒슂븳 쁺뼢쓣 誘몄튇떎뒗 寃껋쓣 븣 닔 엳뿀떎.

삉븳 蹂 뿰援ъ뿉꽌 슫룞洹몃9 슫룞 썑 뿼利앹쑀諛 궗씠넗移댁씤쓽 몴쟻씤 빆紐 以묒쓽 븯굹씤 TNF-α쓽 삁以 냽룄媛 쑀쓽븯寃(p< 0.05) 媛먯냼븯쑝硫, 빆 뿼利앹슂씤쑝濡쒖꽌 씤뒓由곗빆꽦怨 룞留κ꼍솕利앹쓣 媛먯냼떆궎뒗 以묒슂븳 옉슜쓣 븿쑝濡쒖뜥 궗꽦 吏덊솚諛⑹뿉 湲띿젙쟻쑝濡 옉슜븯뒗 븘뵒룷꽖떞쓽 삁以 냽룄뒗 쑀쓽븯寃(p< 0.05) 利앷븿쑝濡쒖뜥 슫룞쓽 湲띿젙쟻씤 슚怨쇰 紐낇솗븯寃 젣떆빐 二쇨퀬 엳떎25. 궗꽦吏덊솚쓽 媛옣 빑떖쟻씤 썝씤뿉 빐떦븯뒗 留뚯꽦쟻 뿼利앹쑀諛쒓낵 愿젴맂 궗씠넗移댁씤쓽 利앷뒗 씤뒓由곗빆꽦, 痍뚯옣꽭룷 愿댁궗, 二쎌궘룞留κ꼍솕利, 떊寃쎌“吏 눜솕 諛 븫꽭룷 利앹떇 벑쓽 썝씤쑝濡 옉슜븯寃 릺硫, 媛옣 몴쟻쑝濡 2삎 떦눊蹂묎낵 떖삁愿 吏덊솚 쑀蹂묐쪧 利앷뿉 빑떖쟻씤 슂씤쑝濡 옉슜븯寃 맂떎. 뵲씪꽌 蹂 뿰援ъ뿉꽌 슫룞洹몃9쓽 뿼利앷젴 궗씠넗移댁씤씤 삁以 TNF-α 諛 븘뵒룷꽖떞 냽룄 벑쓽 湲띿젙쟻씤 蹂솕뒗 슫룞슚怨쇱쓽 以묒슂븳 珥덉젏쓣 留욎텣 삁愿湲곕뒫쓽 빑떖쟻 슂씤씤 삁븬怨 寃쎈룞留 궡以묐쭑 몢猿섏뿉 븳 蹂솕뿉 湲띿젙쟻씤 쁺뼢쓣 誘몄낀쓣 寃껋쑝濡 湲곕맂떎. 蹂 뿰援ъ뿉 쟻슜맂 슫룞듃젅씠떇 鍮꾨쭔 以묐뀈 뿬꽦쓽 떊泥닿뎄꽦 諛 삁以 궗씠넗移댁씤냽룄 벑쓽 湲띿젙쟻씤 蹂솕瑜 넻빐꽌 삁愿湲곕뒫쓽 湲띿젙쟻씤 蹂솕瑜 媛졇삱 닔 엳떎뒗 寃26쓣 遺꾨챸븯寃 솗씤븷 닔 엳뿀떎. 슫룞듃젅씠떇쓽 빆 뿼利앺슚怨쇱 愿젴맂 궗씠넗移댁씤 遺꾨퉬怨쇱젙뿉꽌 以묒슂븯寃 怨좊젮릺뼱빞 븯뒗 遺遺꾩 삁以 궗씠넗移댁씤냽룄뿉 쁺뼢쓣 誘몄튌 닔 엳뒗 洹 遺꾨퉬湲곌씠 洹쇱쑁씪 寃쎌슦 IL-6瑜 鍮꾨’븳 IL-4, IL-7, IL-15, leukemia inhibitory factor 벑 빆 뿼利 옉슜쓣 넻빐꽌 鍮꾨쭔뿉 쓽븳 삁愿湲곕뒫 빐슂씤쓣 뼲젣븯硫, 궗꽦吏덊솚쓽 쑀蹂묐쪧쓣 궙異 닔 엳떎26뒗 愿젏뿉꽌 洹쇱쑁뿉꽌쓽 떒諛깆쭏 諛쒗쁽쓣 룷븿븳 꽭遺쟻씤 蹂솕뼇긽씠 蹂묓뻾릺뼱빞 븷 寃껋씠떎.

蹂 뿰援ъ쓽 媛옣 以묒슂븳 珥덉젏뿉 빐떦븯뒗 삁愿湲곕뒫怨 愿젴맂 寃곌낵뿉꽌 슫룞洹몃9씠 슫룞 쟾뿉 鍮꾪빐 12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 닔異뺢린 諛 씠셿湲 삁븬怨 醫, 슦寃쎈룞留 궡以묐쭑 몢猿섏쓽 紐⑤몢뿉꽌 쑀쓽븯寃(p<0.05) 媛먯냼븯뒗 슚怨쇰 굹깉떎. 寃쎈룞留μ쓽 궡留됯낵 以묐쭑 궡뵾꽭룷, 寃곗껜議곗쭅, 룊솢洹쇱쑝濡 援ъ꽦릺뼱 엳쑝硫 二쎌긽룞留κ꼍솕꽦 諛 삎꽦뿉 엳뼱 吏諛⑹씠 異뺤쟻릺뒗 遺쐞씠떎. Veller 벑27 寃쎈룞留μ쓽 궡以묐쭑 몢猿섎뒗 젙긽씤뿉꽌 0.25–1.5 mm濡 굹굹硫, 엫긽쟻쑝濡 1.0 mm 씠긽씠硫 吏덊솚諛쒖깮 쐞뿕룄媛 넂 寃껋쑝濡 蹂닿퀬븯떎. 洹몃윭굹 븘吏 援궡뿉꽌뒗 젙긽移섏뿉 븳 湲곗씠 솗由쎈릺吏 紐삵븳 긽깭씠떎. 寃쎈룞留μ쓽 궡以묐쭑 몢猿섎뒗 鍮꾨쭔씤씠 넂寃 굹굹硫, 떖洹쇨꼍깋, 뇤議몄쨷 벑쓽 옞옱쟻 쐞뿕슂씤뿉 빐떦븯뒗뜲, 鍮꾨쭔씤뿉 븳 硫뷀遺꾩꽍寃곌낵뿉꽌 泥댁쨷 媛먯냼쓽 젙룄 寃쎈룞留 궡以묐쭑 몢猿섏쓽 媛먯냼 젙룄뒗 넂 긽愿쓣 媛吏 寃껋쑝濡 蹂닿퀬28맂 諛 엳뒗뜲, 蹂 뿰援ъ뿉꽌룄 蹂듯빀슫룞봽濡쒓렇옩 닔뻾 썑 醫뚯슦 寃쎈룞留μ쓽 궡以묐쭑 몢猿섏쓽 媛먯냼 젙룄뒗 泥댁쨷, HbA1c 諛 TG쓽 媛먯냼 젙룄뒗 쑀쓽븳(p<0.05) 긽愿愿怨꾨 굹깂쑝濡쒖뜥 삁愿湲곕뒫 媛쒖꽑쓣 쐞빐꽌뒗 泥댁쨷媛먯냼 뜑遺덉뼱 씤뒓由곌컧닔꽦 諛 삁以 吏吏 媛쒖꽑쓽 以묒슂꽦쓣 紐낇솗븯寃 솗씤븷 닔 엳뿀떎. 理쒓렐 Byrkjeland 벑29 떦눊蹂 솚옄 愿긽룞留μ쭏솚옄瑜 긽쑝濡 蹂 뿰援ъ뿉꽌 룞씪븯寃 쟻슜븳 쑀궛냼슫룞 諛 빆꽦슫룞쓽 蹂듯빀슫룞봽濡쒓렇옩쓽 닔뻾 썑 寃쎈룞留 궡以묐쭑 몢猿섏쓽 쁽븳 媛먯냼瑜 蹂닿퀬븿쑝濡쒖뜥 蹂 뿰援ъ쓽 寃곌낵瑜 뮮諛쏆묠빐二쇨퀬 엳떎. 듅엳 蹂 뿰援ъ쓽 긽옄뱾 寃쎈룞留 궡以묐쭑 몢猿섍 遺遺 젙긽踰붿쐞뿉 룷븿릺뿀쑝굹 12二쇨컙쓽 슫룞 썑 뜑슧 媛쒖꽑릺뒗 寃곌낵瑜 굹깉떎. 씠뒗 떎뼇븳 슂씤뿉 쓽빐 諛쒖깮븯쓣 寃껋쑝濡 깮媛곷릺吏留, 蹂 뿰援ъ쓽 寃곌낵뿉꽌 떊泥닿뎄꽦쓽 湲띿젙쟻씤 蹂솕뿉 쓽븳 삁以 뿼利앹씤옄쓽 媛쒖꽑怨 삁떦 議곗젅젰 벑쓽 媛꾩젒쟻씤 쁺뼢怨 뜑遺덉뼱 듅엳 HbA1c 닔以怨 삁以 TG쓽 쑀쓽븳 媛쒖꽑 삁愿 궡 湲띿젙쟻 蹂솕뿉 겕寃 쁺뼢쓣 誘몄낀쓣 寃껋쑝濡 깮媛곷맂떎.

蹂듯빀슫룞듃젅씠떇뿉 쓽븳 寃쎈룞留 궡以묐쭑 몢猿섏쓽 蹂솕뒗 닔異뺢린 諛 씠셿湲 삁븬쓽 媛쒖꽑슚怨쇱 넂 긽愿꽦쓣 굹깂쑝濡쒖뜥 떎젣쟻씤 삁愿湲곕뒫 媛쒖꽑뿉 겕寃 룄쓣 以 寃껋쑝濡 媛꾩<릺硫, 씠윭븳 슚怨쇰뒗 븙젰 諛 泥댁쟾援댁쓣 룷븿븳 泥대젰뼢긽怨 넂 愿젴꽦쓣 굹깉떎. 듅엳 Fig. 1뿉꽌 굹궃 諛붿 媛숈씠 醫뚭꼍룞留 궡以묐쭑 몢猿섏쓽 蹂솕뒗 닔異뺢린 諛 씠셿湲 삁븬쓽 媛쒖꽑슚怨쇱 쑀쓽븳(p< 0.05) 긽愿꽦쓣 굹깂쑝濡쒖뜥 슫룞슚怨쇱뿉 뵲瑜 삁愿湲곕뒫 諛 援ъ“쓽 媛쒖꽑슚怨쇨 룞諛섏쟻쑝濡 굹굹怨 엳쓬쓣 솗씤븷 닔 엳뿀떎. 鍮꾨쭔 以묐뀈뿬꽦뿉寃뚯꽌 굹궃 떊泥닿뎄꽦怨 泥대젰뼢긽슚怨쇰뒗 떖諛⑹꽭룞쓣 鍮꾨’븳 떖삁愿 吏덊솚쓽 쑀蹂묐쪧쓣 궙異붾뒗 뜲 겕寃 룄쓣 몮 닔 엳떎30뒗 愿젏뿉꽌 蹂 뿰援ъ뿉꽌룄 씠윭븳 슚怨쇨 삁븬 諛 寃쎈룞留 궡以묐쭑 몢猿섎 셿솕떆궎뒗뜲 以묒슂븳 쁺뼢쓣 誘몄튂뒗 寃껋쓣 뙆븙븷 닔 엳뿀쑝硫, 븘슱윭 삁愿湲곕뒫씠 떊泥댁쟻 嫄닿컯긽깭뿉 以묒슂븳 슂씤쑝濡 룷븿맂떎뒗 寃껋쓣 솗씤븷 닔 엳뿀떎. 떒, 蹂 뿰援щ뒗 40 룓寃 씠쟾쓽 뿬꽦쓣 긽쑝濡 븿쑝濡쒖꽌 꽦蹂꾧낵 뿰졊뿉 뵲瑜 젣븳쟻 슚怨쇰줈 媛꾩<릺硫, 븘슱윭 떊泥닿뎄꽦쓣 룷븿븳 삁以 蹂씤쓽 蹂솕 벑씠 떇씠꽠痍⑥뿉 뵲瑜 쁺뼢씠 옉슜븷 媛뒫꽦씠 넂뜲 諛섑빐꽌 떇씠넻젣瑜 떎떆븯吏 紐삵븳 遺遺꾩씠 젣븳젏쑝濡 媛꾩<맂떎.

寃곕줎쟻쑝濡 궗꽦 利앺썑援곗쓣 굹궦 鍮꾨쭔 以묐뀈뿬꽦쓣 긽쑝濡 12二쇨컙쓽 蹂듯빀슫룞봽濡쒓렇옩쓣 닔뻾븳 寃곌낵 떊泥닿뎄꽦, 삁以 湲猷⑥퐫뒪 궗 蹂씤 諛 吏吏 蹂씤씠 媛쒖꽑릺뿀쑝硫, 泥대궡 뿼利앷낵 愿젴맂 삁以 궗씠넗移댁씤냽룄쓽 湲띿젙쟻씤 蹂솕瑜 넻빐꽌 삁愿湲곕뒫 愿젴吏몴씤 삁븬 諛 寃쎈룞留 궡以묐쭑 몢猿섏쓽 쁽븳 媛쒖꽑씠 씠猷⑥뼱吏뒗 寃껋쓣 솗씤븷 닔 엳뿀떎.

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

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